In 2016, on the cusp of the 10-year anniversary of Denny Sanford’s historic $400 million gift to Sanford Health, the health system committed to building a permanent home to capture the spirit and history of its greatest benefactor and namesake.

Supported by the private philanthropy of donors inspired by Mr. Sanford’s generosity, construction on the 18,000 square-foot Sanford House began immediately and continued through late 2017. In July 2018, Sanford Health celebrated the official grand opening of the House.

Today, visitors of all ages are invited to explore dynamic displays and exhibits that illustrate the far-reaching impact of Mr. Sanford’s extraordinary philanthropy, and hopefully open hearts and minds to the transformative power of giving.


What can I expect to see?

The Sanford House is an 18,000-square-foot, two-story stone and brick building with a three-story signature Sanford Tower. Constructed in the Collegiate Gothic Sanford Health style, the building reflects the honored tradition of the health system and legacy of its benefactor, Denny Sanford.

Located on the 40-acre campus of Sanford Health’s corporate headquarters and research center in northeast Sioux Falls, S.D., the Sanford House sits prominently on the Dakota prairie amidst grassland, ponds and horse pastures.

Inside the building, a few of the special details to look forward to include:

  • Collections of Mr. Sanford’s personal memorabilia that tell his fascinating life story.
  • The kitchen table where Mr. Sanford and Kelby Krabbenhoft, president and CEO of Sanford Health, brokered the donation that led to Sanford Health’s transformation and renaming.
  • Interactive exhibits that demonstrate the power of philanthropy.
  • Recognition Hall, a tribute to Mr. Sanford and the health care causes he has championed, including children’s health, medical research, breast cancer and genomic medicine.
  • The Legacy Walks, two balconies flanking the second-floor overlooks, tell Mr. Sanford’s personal story, from his childhood to business career to his philanthropic accomplishments.
  • A donor wall celebrating all the friends of Sanford Health whose generosity continues to support the initiatives catalyzed by Mr. Sanford’s philanthropy.


How is the Sanford House used?

First and foremost, the Sanford House is open all year long to educate and inspire the public about the power of philanthropy and life and legacy of Denny Sanford, the world’s preeminent health care philanthropist.

The House also includes office space for the Sanford Health Foundation and meeting space for the Sanford International Board and Sanford leadership. Additionally, it is frequently used as a venue for press and fundraising events as well as donor celebrations.


What is the significance of its location?

While Mr. Sanford’s vision and generosity extends from coast to coast and beyond, there is no more fitting place to honor and preserve his legacy than in Sioux Falls, S.D., where the story of Sanford Health began.

In 2007, Mr. Sanford entrusted Sanford Health (then a regional provider known as Sioux Valley) with a $400 million gift — the largest known gift to an American health care organization — to achieve ambitious clinical and research goals collectively called the “Sanford Initiatives.”

That gift set the health system on a trajectory of rapid growth, transforming the health care landscape across the Upper Midwest and positioning it as a global leader in research and discovery. Today, Sanford Health is one of the largest integrated nonprofit health systems in the nation, operating 44 medical centers, 482 clinics and more than 200 Good Samaritan Society senior care locations in 26 states and nine countries.

The address of the Sanford House is 2335 Road to the Cure, referring to both the goal of Mr. Sanford’s philanthropy and his birthday: Dec. 23, 1935.

Press & Media

Stories related to the Sanford House and Denny Sanford

Denny Sanford pledged to match the next $5 million donated to the Sanford Lorraine Cross Award. In his own words, he explains why he believes in this innovation prize. 


Leaders from Sanford Health and the U.S. Department of Veterans Affairs convened in Washington, D.C., to announce a partnership with major implications for the health care of veterans and the future of precision medicine. The program is funded by a $25 million donation from philanthropist Denny Sanford.


An impromptu tour of Ava’s House by Sanford inspired a $1 million gift from philanthropist Denny Sanford. While in Sioux Falls for the grand opening of the Sanford House, Mr. Sanford made a point to visit the new multigenerational hospice facility. 


The award was presented during a ribbon-cutting ceremony for the Sanford House — a $6-million tribute to Mr. Sanford’s legacy in health care — underscoring the significance of the new building.


At an intimate event on December 4, Denny Sanford was celebrated at the Sanford House, a new facility in Sioux Falls that bears the story of his life and legacy as health care’s greatest philanthropist.


Still in its final stages of construction, the new Sanford House is capturing the attention of drivers traveling I-229 through northeast Sioux Falls.


Sanford Health is honoring the enduring legacy of philanthropist Denny Sanford with the construction of the Sanford House, a facility that will pay tribute to the health system’s namesake and contain the Sanford Health Foundation offices and an event space.